4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)-
Hirsutenone
CAS: 41137-87-5
Molecular Formula: C19H20O5
4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)- - Names and Identifiers
| Name | Hirsutenone |
| Synonyms | Hirsutenone (4E)-1,7-Bis(3,4-dihydroxyphenyl)-4-hepten-3-one 4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)- |
| CAS | 41137-87-5 |
4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)- - Physico-chemical Properties
| Molecular Formula | C19H20O5 |
| Molar Mass | 328.36 |
| Density | 1.313±0.06 g/cm3(Predicted) |
| Boling Point | 622.0±55.0 °C(Predicted) |
| pKa | 9.76±0.10(Predicted) |
| Storage Condition | -20°C |
| Use | Cytotoxic |
| In vitro study | Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes.Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes.Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase. |
4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)- - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50 - Very Toxic to aquatic organisms |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)- - Reference Information
| biological activity | Hirsutenone is an active diheptanone contained in Alder, which has anti-inflammatory, anti-tumor and anti-atopic dermatitis and other biological activities. Hirsutenone attenuates adipogenesis and can bind directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used in the study of obesity. |
Last Update：2024-04-09 21:54:55
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